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Article

ATM and genome maintenance: defining its role in breast cancer susceptibility.

Journal of mammary gland biology and neoplasia - 1 Jul 2004

Khanna Kum Kum, Chenevix-Trench Georgia

Abstract excerpt

The ATM gene is mutated in ataxia-telangiectasia (A-T), a genetic instability syndrome characterized by increased cancer risk, as well as other features. Recent studies have shown that the ATM protein kinase plays a critical role in maintaining genome integrity by activating a biochemical chain reaction that in turn leads to cell cycle checkpoint activation and repair of DNA damage. ATM targets include well-known...

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Source

Identifiers

PMID: 15557798
DOI: 10.1023/B:JOMG.0000048772.92326.a1

Genes

ATM
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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