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Cellular transformation of human mammary epithelial cells by SATB2

1 Feb 2017

Abstract excerpt

Breast tumors are heterogeneous and carry a small population of progenitor cells that can produce various subtypes of breast cancer. SATB2 (special AT-rich binding protein-2) is a newly identified transcription factor and epigenetic regulator. It is highly expressed in embryonic stem cells, but not in adult tissues, and regulates pluripotency-maintaining factors. However, the molecular mechanisms by which SATB2...

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PMID: 28167342
DOI: 10.1016/j.scr.2017.01.011

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