Invasive breast carcinomas with ATM gene variants of uncertain significance share distinct histopathologic features.

doi:10.1111/tbj.12930

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Article

Invasive breast carcinomas with ATM gene variants of uncertain significance share distinct histopathologic features.

The breast journal - 1 May 2018

Abdulrahman Ahmed A, Heintzelman Rebecca C, Corbman Melanie, Garcia Fernando U

Abstract excerpt

The increasing availability of next-generation sequencing for clinical research dramatically improved our understanding of breast cancer genetics and resulted in detection of new mutation variants. Cancer risk data relating to some of these variants are insufficient, prompting the designation of variants of uncertain significance (VUS). The histopathologic characteristics of these variants have not been...

Topics

Adult
Aged
Ataxia Telangiectasia Mutated Proteins
Breast Neoplasms
Breast Neoplasms, Male
Female
Genetic Variation
Humans
Lymphocytes, Tumor-Infiltrating
Male
Middle Aged

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PMID: 28986972
DOI: 10.1111/tbj.12930

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