Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis.

Nature - 13 Mar 2008

Han Hye-Jung, Russo Jose, Kohwi Yoshinori, Kohwi-Shigematsu Terumi

Abstract excerpt

Mechanisms underlying global changes in gene expression during tumour progression are poorly understood. SATB1 is a genome organizer that tethers multiple genomic loci and recruits chromatin-remodelling enzymes to regulate chromatin structure and gene expression. Here we show that SATB1 is expressed by aggressive breast cancer cells and its expression level has high prognostic significance (P < 0.0001),...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Polarity
Share to Epigenesis, Genetic
Share to Lymphatic Metastasis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Matrix Attachment Region Binding Proteins

Share to Mice, Nude

Share to Neoplasm Metastasis

Share to Neoplasm Transplantation

Share to RNA Interference

Source

Identifiers

PMID: 18337816
DOI: 10.1038/nature06781

Genes

SATB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis.PMID 18337816Read ↗

Genome Organizer SATB1 selectively activates a defined subset of EMT genes driving metastatic breast cancerSemantic proximity Read ↗

The mRNA expression of SATB1 and SATB2 in human breast cancerSemantic proximity Read ↗

Is SATB1 a master regulator in breast cancer growth and metastasis?Semantic proximity Read ↗

Cellular transformation of human mammary epithelial cells by SATB2Semantic proximity Read ↗

Multiple effects of the special AT‐rich binding protein 1 (SATB1) in colon carcinomaSemantic proximity Read ↗

The transcriptional repressor BCL11A promotes breast cancer metastasisSemantic proximity Read ↗

ATM suppresses SATB1-induced malignant progression in breast epithelial cells.Semantic proximity Read ↗

SATB2 is a novel biomarker and therapeutic target for cancerSemantic proximity Read ↗

Overexpression and involvement of special AT‐rich sequence binding protein 1 in multidrug resistance in human breast carcinoma cellsSemantic proximity Read ↗

Comparative analysis of the AIB1 interactome in breast cancer reveals MTA2 as a repressive partner which silences E-Cadherin to promote EMT and associates with a pro-metastatic phenotype.Semantic proximity Read ↗

Loss of special <scp>AT</scp>‐rich sequence‐binding protein 1 (<scp>SATB</scp>1) predicts poor survival in patients with colorectal cancerSemantic proximity Read ↗

SATB2 Expression in Human Tumors: A Tissue Microarray Study on More Than 15 000 TumorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.