Article

Adaptive response to BET inhibition induces therapeutic vulnerability to MCL1 inhibitors in breast cancer

2019-07-23

Abstract excerpt

The development of effective targeted therapies for the treatment of basal-like breast cancers remains challenging. Here, we demonstrate that BET inhibition induces a multi-faceted adaptive response program leading to MCL1 protein-driven evasion of apoptosis in breast cancers. Consequently, co-targeting MCL1 and BET is highly synergistic in in vitro and in vivo breast cancer models. Drug response and genomics an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7563612b-9b7f-5e87-aacb-9169058face4
DOI: 10.1101/711895

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Adaptive response to BET inhibition induces therapeutic vulnerability to MCL1 inhibitors in breast cancerDOI 10.1101/711895Read

The impact of lipid metabolism on breast cancer: a review about its role in tumorigenesis and immune escapeSemantic proximity Read

BET proteins in abnormal metabolism, inflammation, and the breast cancer microenvironmentSemantic proximity Read

MYC-Driven Pathways in Breast Cancer SubtypesSemantic proximity Read

ESR1-Activating Mutations Confer Metabolic Vulnerabilities in ER+ Breast Cancer.Semantic proximity Read

Lipid Metabolism Reprogramming and Trastuzumab Resistance in Breast Cancer Cell Lines Overexpressing the ERBB2 Membrane ReceptorSemantic proximity Read

Identification and validation of a prognostic signature of drug resistance and mitochondrial energy metabolism-related differentially expressed genes for breast cancerSemantic proximity Read

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancerSemantic proximity Read

ADAR1 Regulates Lipid Remodeling to Dictate Ferroptosis SensitivitySemantic proximity Read

Unraveling Vulnerabilities in Endocrine Therapy-Resistant HER2+/ER+ Breast CancerSemantic proximity Read

The role of CPT1A as a biomarker of breast cancer progression: a bioinformatic approachSemantic proximity Read

Lipid Metabolism Reprogramming Is Associated with Trastuzumab Resistance in ERBB2+ Breast Cancer Cell LinesSemantic proximity Read

Omics Analysis of Chemoresistant Triple Negative Breast Cancer Cells Reveals Novel Metabolic VulnerabilitiesSemantic proximity Read