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Article

DNA mismatch repair promotes APOBEC3-mediated diffuse hypermutation in human cancers.

Nature genetics - 1 Sept 2020

Mas-Ponte David, Supek Fran

Abstract excerpt

Certain mutagens, including the APOBEC3 (A3) cytosine deaminase enzymes, can create multiple genetic changes in a single event. Activity of A3s results in striking 'mutation showers' occurring near DNA breakpoints; however, less is known about the mechanisms underlying the majority of A3 mutations. We classified the diverse patterns of clustered mutagenesis in tumor genomes, which identified a new A3 pattern:...

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Identifiers

PMID: 32747826
DOI: 10.1038/s41588-020-0674-6
PMCID: PMC7610516

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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