Article
The role of IL-17-producing Foxp3+ CD4+ T cells in inflammatory bowel disease and colon cancer.
Clinical immunology (Orlando, Fla.) - 1 Aug 2013
Li Lequn, Boussiotis Vassiliki A
Abstract excerpt
The intestinal epithelium and underlying lamina propria contain T cells that play important roles in maintaining colonic homeostasis. These T cells mediate substantial and specific regulation to ensure that pathogenic microorganisms are eliminated while commensal bacteria are tolerated. There is considerable evidence supporting the notion that the altered ratio between Foxp3(+)CD4(+) T regulatory cells and T...
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