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Article

Batf-dependent Th17 cells critically regulate IL-23 driven colitis-associated colon cancer

2 Apr 2015

Abstract excerpt

OBJECTIVES: IBDs have an increased risk for development of colorectal cancer (CRC). Here, we aimed at the characterisation of the functional role of Th17-associated transcription factors in sporadic and colitis-associated colon cancer in vivo. DESIGN: We used mice deficient or transgenic for the activating protein 1 family member basic leucine zipper transcription factor ATF-like (Batf) to evaluate the role of...

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Identifiers

PMID: 25838550
DOI: 10.1136/gutjnl-2014-308227

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