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Article

The noncoding RNAs SNORD50A and SNORD50B bind K-Ras and are recurrently deleted in human cancer.

Nature genetics - 1 Jan 2016

Siprashvili Zurab, Webster Dan E, Johnston Danielle, Shenoy Rajani M, Ungewickell Alexander J, Bhaduri Aparna, Flockhart Ross, Zarnegar Brian J, Che Yonglu, Meschi Francesca, Puglisi Joseph D, Khavari Paul A

Abstract excerpt

Small nucleolar RNAs (snoRNAs) are conserved noncoding RNAs best studied as ribonucleoprotein (RNP) guides in RNA modification. To explore their role in cancer, we compared 5,473 tumor-normal genome pairs to identify snoRNAs with frequent copy number loss. The SNORD50A-SNORD50B snoRNA locus was deleted in 10-40% of 12 common cancers, where its loss was associated with reduced survival. A human protein microarray...

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Identifiers

PMID: 26595770
DOI: 10.1038/ng.3452
PMCID: PMC5324971

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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