Article
Oncogenic CDK13 mutations impede nuclear RNA surveillance.
Science (New York, N.Y.) - 21 Apr 2023
Insco Megan L, Abraham Brian J, Dubbury Sara J, Kaltheuner Ines H, Dust Sofia, Wu Constance, Chen Kevin Y, Liu David, Bellaousov Stanislav, Cox Anna M, Martin Benjamin J E, Zhang Tongwu, Ludwig Calvin G, Fabo Tania, Modhurima Rodsy, Esgdaille Dakarai E, Henriques Telmo, Brown Kevin M, Chanock Stephen J, Geyer Matthias, Adelman Karen, Sharp Phillip A, Young Richard A, Boutz Paul L, Zon Leonard I
Abstract excerpt
RNA surveillance pathways detect and degrade defective transcripts to ensure RNA fidelity. We found that disrupted nuclear RNA surveillance is oncogenic. Cyclin-dependent kinase 13 (CDK13) is mutated in melanoma, and patient-mutated CDK13 accelerates zebrafish melanoma. CDK13 mutation causes aberrant RNA stabilization. CDK13 is required for ZC3H14 phosphorylation, which is necessary and sufficient to promote...
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