Article

CRISPR-mediated Correction of Oncogenic AS-NMD in Splicing Factor Mutant Cancer

2026-07-29

Abstract excerpt

Alternative splicing coupled to nonsense-mediated mRNA decay (AS-NMD) evolved as a master regulator of gene expression. Dysregulated AS-NMD has been identified as the root of many human maladies, from developmental defects to deadly cancer. Poison exons (PEs) are highly conserved alternative exons that contain a premature termination codon and elicit AS-NMD when included in a transcript. Cancer cells often exploit...

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Literature Corpus work: a297e72e-822c-5b9e-9e5a-6b56421fd6b2
DOI: 10.64898/2026.07.28.739648

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