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Article

CHES1/FOXN3 regulates cell proliferation by repressing PIM2 and protein biosynthesis

8 Jan 2014

Abstract excerpt

The expression of the forkhead transcription factor checkpoint suppressor 1 (CHES1), also known as FOXN3, is reduced in many types of cancers. We show here that CHES1 decreases protein synthesis and cell proliferation in tumor cell lines but not in normal fibroblasts. Conversely, short hairpin RNA-mediated depletion of CHES1 increases tumor cell proliferation. Growth suppression depends on the CHES1 forkhead...

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PMID: 24403608
DOI: 10.1091/mbc.e13-02-0110

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