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Article

A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.

Cell - 29 May 2009

Luo Ji, Emanuele Michael J, Li Danan, Creighton Chad J, Schlabach Michael R, Westbrook Thomas F, Wong Kwok-Kin, Elledge Stephen J

Abstract excerpt

Oncogenic mutations in the small GTPase Ras are highly prevalent in cancer, but an understanding of the vulnerabilities of these cancers is lacking. We undertook a genome-wide RNAi screen to identify synthetic lethal interactions with the KRAS oncogene. We discovered a diverse set of proteins whose depletion selectively impaired the viability of Ras mutant cells. Among these we observed a strong enrichment for...

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Source

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Identifiers

PMID: 19490893
DOI: 10.1016/j.cell.2009.05.006
PMCID: PMC2768667

Genes

KRAS
PLK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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