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Article

Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells.

Journal of neurochemistry - 1 May 2008

Plowey Edward D, Cherra Salvatore J, Liu Yong-Jian, Chu Charleen T

Abstract excerpt

Neuritic retraction represents a prominent feature of the degenerative phenotype associated with mutations in leucine rich repeat kinase 2 (LRRK2) that are implicated in autosomal dominant and some cases of sporadic Parkinson's disease. Alterations in macroautophagy, the vacuolar catabolism of cytoplasmic constituents, have been described in Parkinson's disease. In this study, we utilized retinoic-acid...

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Source

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Identifiers

PMID: 18182054
DOI: 10.1111/j.1471-4159.2008.05217.x
PMCID: PMC2361385

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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