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Article

Mutant LRRK2 enhances glutamatergic synapse activity and evokes excitotoxic dendrite degeneration.

Biochimica et biophysica acta - 1 Sept 2014

Plowey Edward D, Johnson Jon W, Steer Erin, Zhu Wan, Eisenberg David A, Valentino Natalie M, Liu Yong-Jian, Chu Charleen T

Abstract excerpt

Mutations in leucine-rich repeat kinase 2 (LRRK2), which are associated with autosomal dominant Parkinson's disease, elicit progressive dendrite degeneration in neurons. We hypothesized that synaptic dysregulation contributes to mutant LRRK2-induced dendritic injury. We performed in vitro whole-cell voltage clamp studies of glutamatergic receptor agonist responses and glutamatergic synaptic activity in cultured...

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Identifiers

PMID: 24874075
DOI: 10.1016/j.bbadis.2014.05.016
PMCID: PMC4144018

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Mutant LRRK2 enhances glutamatergic synapse activity and evokes excitotoxic dendrite degeneration.PMID 24874075Read ↗

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