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Article

Loss of mitochondrial Ca2+ response and CaMKII/ERK activation by LRRK2R1441G mutation correlate with impaired depolarization-induced mitophagy.

Cell communication and signaling : CCS - 10 Oct 2024

Chang Eunice Eun-Seo, Liu Huifang, Choi Zoe Yuen-Kiu, Malki Yasine, Zhang Steffi Xi-Yue, Pang Shirley Yin-Yu, Kung Michelle Hiu-Wai, Ramsden David B, Ho Shu-Leong, Ho Philip Wing-Lok

Abstract excerpt

BACKGROUND: Stress-induced activation of ERK/Drp1 serves as a checkpoint in the segregation of damaged mitochondria for autophagic clearance (mitophagy). Elevated cytosolic calcium (Ca2+) activates ERK, which is pivotal to mitophagy initiation. This process is altered in Parkinson's disease (PD) with mutations in leucine-rich repeat kinase 2 (LRRK2), potentially contributing to mitochondrial dysfunction....

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Identifiers

PMID: 39390438
DOI: 10.1186/s12964-024-01844-y
PMCID: PMC11465656

Genes

MCU

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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