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Article

Mitochondrial Calcium Dysregulation Contributes to Dendrite Degeneration Mediated by PD/LBD-Associated LRRK2 Mutants.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Nov 2017

Verma Manish, Callio Jason, Otero P Anthony, Sekler Israel, Wills Zachary P, Chu Charleen T

Abstract excerpt

Mutations in leucine-rich repeat kinase 2 (LRRK2) contribute to development of late-onset familial Parkinson's disease (PD), with clinical features of motor and cognitive dysfunction indistinguishable from sporadic PD. Calcium dysregulation plays an important role in PD pathogenesis, but the mechanisms of neurodegeneration remain unclear. Recent reports indicate enhanced excitatory neurotransmission in cortical...

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Source

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Identifiers

PMID: 29038245
DOI: 10.1523/JNEUROSCI.3791-16.2017
PMCID: PMC5688524

Genes

MCU
MICU1
MAPK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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