Article
Single nucleotide polymorphism at exon 7 splice acceptor site of OAS1 gene determines response of hepatitis C virus patients to interferon therapy.
Journal of gastroenterology and hepatology - 1 May 2011
El Awady Mostafa K, Anany Mohamed A, Esmat Gamal, Zayed Naglaa, Tabll Ashraf A, Helmy Amr, El Zayady Abdel Rahman, Abdalla Mohga S, Sharada Hayat M, El Raziky Maissa, El Akel Wafaa, Abdalla Shadia, Bader El Din Noha G
Abstract excerpt
BACKGROUND AND AIM: Response to interferon therapy and disease progression in hepatitis C virus (HCV) infected patients differs among individuals, suggesting a possibility of a contribution of host genetic factors. 2'-5'-oligoadenylate synthetase 1 (OAS1), an important component of the innate immune system with a proven antiviral function, may therefore have a relationship with the response to interferon therapy...
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