Article
Genetic variation in OAS1 is a risk factor for initial infection with West Nile virus in man.
PLoS pathogens - 1 Feb 2009
Lim Jean K, Lisco Andrea, McDermott David H, Huynh Linda, Ward Jerrold M, Johnson Bernard, Johnson Hope, Pape John, Foster Gregory A, Krysztof David, Follmann Dean, Stramer Susan L, Margolis Leonid B, Murphy Philip M
Abstract excerpt
West Nile virus (WNV) is a re-emerging pathogen that can cause fatal encephalitis. In mice, susceptibility to WNV has been reported to result from a single point mutation in oas1b, which encodes 2'-5' oligoadenylate synthetase 1b, a member of the type I interferon-regulated OAS gene family involved in viral RNA degradation. In man, the human ortholog of oas1b appears to be OAS1. The 'A' allele at SNP rs10774671...
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