Article

Altered polyadenylation site usage in SERPINA1 3’UTR in response to cellular stress affects A1AT protein expression

2024-09-14

Abstract excerpt

Alternative polyadenylation results in different 3’ isoforms of messenger RNA (mRNA) transcripts. Alternative polyadenylation in the 3’ untranslated region (3’UTR) can alter RNA localization, stability and translational efficiency. The SERPINA1 mRNA has two distinct 3’ UTR isoforms, both of which express the protease inhibitor α-1-antitrypsin (A1AT). A1AT is an acute phase protein that is expressed and secreted f...

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Literature Corpus work: 1820a8df-6161-5a17-af04-c5873bbb762e
DOI: 10.1101/2024.09.13.612749

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Altered polyadenylation site usage in SERPINA1 3’UTR in response to cellular stress affects A1AT protein expressionDOI 10.1101/2024.09.13.612749Read

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