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Article

The COMT val158met polymorphism and brain morphometry in healthy young adults.

Neuroscience letters - 11 Sept 2006

Zinkstok Janneke, Schmitz Nicole, van Amelsvoort Therese, de Win Maartje, van den Brink Wim, Baas Frank, Linszen Don

Abstract excerpt

Catechol-O-methyltransferase (COMT) is the most important mechanism for dopamine degradation in the prefrontal cortex and contains a functional polymorphism (val(158)met) influencing enzyme activity. The low-activity met allele has been associated with better performance on cognitive tasks relying on the prefrontal cortex. Whether COMT also affects brain structure, is still unclear. This study investigated the...

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Source

Identifiers

PMID: 16857316
DOI: 10.1016/j.neulet.2006.06.034

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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