Article
Role of transmitted Gag CTL polymorphisms in defining replicative capacity and early HIV-1 pathogenesis.
PLoS pathogens - 1 Jan 2012
Prince Jessica L, Claiborne Daniel T, Carlson Jonathan M, Schaefer Malinda, Yu Tianwei, Lahki Shabir, Prentice Heather A, Yue Ling, Vishwanathan Sundaram A, Kilembe William, Goepfert Paul, Price Matthew A, Gilmour Jill, Mulenga Joseph, Farmer Paul, Derdeyn Cynthia A, Tang Jiaming, Heckerman David, Kaslow Richard A, Allen Susan A, Hunter Eric
Abstract excerpt
Initial studies of 88 transmission pairs in the Zambia Emory HIV Research Project cohort demonstrated that the number of transmitted HLA-B associated polymorphisms in Gag, but not Nef, was negatively correlated to set point viral load (VL) in the newly infected partners. These results suggested that accumulation of CTL escape mutations in Gag might attenuate viral replication and provide a clinical benefit during...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.