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Article

Pol-Driven Replicative Capacity Impacts Disease Progression in HIV-1 Subtype C Infection.

Journal of virology - 1 Oct 2018

Ojwach Doty B A, MacMillan Daniel, Reddy Tarylee, Novitsky Vladimir, Brumme Zabrina L, Brockman Mark A, Ndung'u Thumbi, Mann Jaclyn K

Abstract excerpt

CD8+ T cell-mediated escape mutations in Gag can reduce HIV-1 replication capacity (RC) and alter disease progression, but less is known about immune-mediated attenuation in other HIV-1 proteins. We generated 487 recombinant viruses encoding RT-integrase from individuals with chronic (n = 406) and recent (n = 81) HIV-1 subtype C infection and measured their in vitro RC using a green fluorescent protein (GFP)...

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Share to CD4 Lymphocyte Count
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to gag Gene Products, Human Immunodeficiency Virus

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Source

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Identifiers

PMID: 29997209
DOI: 10.1128/JVI.00811-18
PMCID: PMC6146804

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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