Phenotypic properties of transmitted founder HIV-1.

doi:10.1073/pnas.1304288110

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Article

Phenotypic properties of transmitted founder HIV-1.

Proceedings of the National Academy of Sciences of the United States of America - 23 Apr 2013

Parrish Nicholas F, Gao Feng, Li Hui, Giorgi Elena E, Barbian Hannah J, Parrish Erica H, Zajic Lara, Iyer Shilpa S, Decker Julie M, Kumar Amit, Hora Bhavna, Berg Anna, Cai Fangping, Hopper Jennifer, Denny Thomas N, Ding Haitao, Ochsenbauer Christina, Kappes John C, Galimidi Rachel P, West Anthony P, Bjorkman Pamela J, Wilen Craig B, Doms Robert W, O'Brien Meagan, Bhardwaj Nina, Borrow Persephone, Haynes Barton F, Muldoon Mark, Theiler James P, Korber Bette, Shaw George M, Hahn Beatrice H

Abstract excerpt

Defining the virus-host interactions responsible for HIV-1 transmission, including the phenotypic requirements of viruses capable of establishing de novo infections, could be important for AIDS vaccine development. Previous analyses have failed to identify phenotypic properties other than chemokine receptor 5 (CCR5) and CD4+ T-cell tropism that are preferentially associated with viral transmission. However, most...

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PMID: 23542380
DOI: 10.1073/pnas.1304288110
PMCID: PMC3637789

Genes

CCR5

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