Article
HLA allele sharing and HIV type 1 viremia in seroconverting Zambians with known transmitting partners.
AIDS research and human retroviruses - 1 Jan 2004
Tang Jianming, Tang Shenghui, Lobashevsky Elena, Zulu Isaac, Aldrovandi Grace, Allen Susan, Kaslow Richard A
Abstract excerpt
Rapid HIV type 1 (HIV-1) mutation coupled with immune evasion poses a major obstacle to effective interventions. In particular, transmission of HIV-1 from a donor partner (transmitter) to a recipient (seroconverter) with similar antigen-presenting molecules (i.e., human leukocyte antigens, HLA) may favor or expedite viral adaptation to host immune responses. Our PCR-based HLA-A, HLA-B, and HLA-DRB1 genotyping for...
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