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Article

Central role of reverting mutations in HLA associations with human immunodeficiency virus set point.

Journal of virology - 1 Sept 2008

Matthews Philippa C, Prendergast Andrew, Leslie Alasdair, Crawford Hayley, Payne Rebecca, Rousseau Christine, Rolland Morgane, Honeyborne Isobella, Carlson Jonathan, Kadie Carl, Brander Christian, Bishop Karen, Mlotshwa Nonkululeko, Mullins James I, Coovadia Hoosen, Ndung'u Thumbi, Walker Bruce D, Heckerman David, Goulder Philip J R

Abstract excerpt

Much uncertainty still exists over what T-cell responses need to be induced by an effective human immunodeficiency virus (HIV) vaccine. Previous studies have hypothesized that the effective CD8(+) T-cell responses are those driving the selection of escape mutations that reduce viral fitness and t...

Read the complete abstract on PubMed

Topics

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Share to CD8-Positive T-Lymphocytes
Share to CD4 Lymphocyte Count

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Products, gag

Share to Gene Products, nef

Share to Gene Products, pol

Share to HLA Antigens

Share to Sequence Analysis, RNA

Share to Viral Load

Source

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Identifiers

PMID: 18596105
DOI: 10.1128/JVI.00580-08
PMCID: PMC2519667

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18596105-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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