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Article

Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipients.

The Journal of experimental medicine - 12 May 2008

Goepfert Paul A, Lumm Wendy, Farmer Paul, Matthews Philippa, Prendergast Andrew, Carlson Jonathan M, Derdeyn Cynthia A, Tang Jianming, Kaslow Richard A, Bansal Anju, Yusim Karina, Heckerman David, Mulenga Joseph, Allen Susan, Goulder Philip J R, Hunter Eric

Abstract excerpt

In a study of 114 epidemiologically linked Zambian transmission pairs, we evaluated the impact of human leukocyte antigen class I (HLA-I)-associated amino acid polymorphisms, presumed to reflect cytotoxic T lymphocyte (CTL) escape in Gag and Nef of the virus transmitted from the chronically infected donor, on the plasma viral load (VL) in matched recipients 6 mo after infection. CTL escape mutations in Gag and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18426987
DOI: 10.1084/jem.20072457
PMCID: PMC2373834

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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