Article
Human leukocyte antigens and HIV type 1 viral load in early and chronic infection: predominance of evolving relationships.
PloS one - 10 Mar 2010
Tang Jianming, Malhotra Rakhi, Song Wei, Brill Ilene, Hu Liangyuan, Farmer Paul K, Mulenga Joseph, Allen Susan, Hunter Eric, Kaslow Richard A
Abstract excerpt
BACKGROUND: During untreated, chronic HIV-1 infection, plasma viral load (VL) is a relatively stable quantitative trait that has clinical and epidemiological implications. Immunogenetic research has established various human genetic factors, especially human leukocyte antigen (HLA) variants, as independent determinants of VL set-point. METHODOLOGY/PRINCIPAL FINDINGS: To identify and clarify HLA alleles that are...
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