Article
Favorable and unfavorable HLA class I alleles and haplotypes in Zambians predominantly infected with clade C human immunodeficiency virus type 1.
Journal of virology - 1 Aug 2002
Tang Jianming, Tang Shenghui, Lobashevsky Elena, Myracle Angela D, Fideli Ulgen, Aldrovandi Grace, Allen Susan, Musonda Rosemary, Kaslow Richard A
Abstract excerpt
The setpoint of viral RNA concentration (viral load [VL]) during chronic human immunodeficiency virus type 1 (HIV-1) infection reflects a virus-host equilibration closely related to CD8(+) cytotoxic T-lymphocyte (CTL) responses, which rely heavily on antigen presentation by the human major histocompatibility complex (MHC) (i.e., HLA) class I molecules. Differences in HIV-1 VL among 259 mostly clade C...
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