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Article

HIV-1 variants are archived throughout infection and persist in the reservoir.

PLoS pathogens - 1 Jun 2020

Brooks Kelsie, Jones Bradley R, Dilernia Dario A, Wilkins Daniel J, Claiborne Daniel T, McInally Samantha, Gilmour Jill, Kilembe William, Joy Jeffrey B, Allen Susan A, Brumme Zabrina L, Hunter Eric

Abstract excerpt

The HIV-1 reservoir consists of latently infected cells that persist despite antiretroviral therapy (ART). Elucidating the proviral genetic composition of the reservoir, particularly in the context of pre-therapy viral diversity, is therefore important to understanding reservoir formation and the persistence of latently infected cells. Here we investigate reservoir proviral variants from 13 Zambian...

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Identifiers

PMID: 32492044
DOI: 10.1371/journal.ppat.1008378
PMCID: PMC7295247

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