Article
Balance between transmitted HLA preadapted and nonassociated polymorphisms is a major determinant of HIV-1 disease progression.
The Journal of experimental medicine - 19 Sept 2016
Mónaco Daniela C, Dilernia Dario A, Fiore-Gartland Andrew, Yu Tianwei, Prince Jessica L, Dennis Kristine K, Qin Kai, Schaefer Malinda, Claiborne Daniel T, Kilembe William, Tang Jianming, Price Matt A, Farmer Paul, Gilmour Jill, Bansal Anju, Allen Susan, Goepfert Paul, Hunter Eric
Abstract excerpt
HIV-1 adapts to a new host through mutations that facilitate immune escape. Here, we evaluate the impact on viral control and disease progression of transmitted polymorphisms that were either preadapted to or nonassociated with the new host's HLA. In a cohort of 169 Zambian heterosexual transmission pairs, we found that almost one-third of possible HLA-linked target sites in the transmitted virus Gag protein are...
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