Article
Short telomere length is associated with impaired cognitive performance in European ancestry cohorts.
Translational psychiatry - 18 Apr 2017
Hägg S, Zhan Y, Karlsson R, Gerritsen L, Ploner A, van der Lee S J, Broer L, Deelen J, Marioni R E, Wong A, Lundquist A, Zhu G, Hansell N K, Sillanpää E, Fedko I O, Amin N A, Beekman M, de Craen A J M, Degerman S, Harris S E, Kan K-J, Martin-Ruiz C M, Montgomery G W, Adolfsson A N, Reynolds C A, Samani N J, Suchiman H E D, Viljanen A, von Zglinicki T, Wright M J, Hottenga J-J, Boomsma D I, Rantanen T, Kaprio J A, Nyholt D R, Martin N G, Nyberg L, Adolfsson R, Kuh D, Starr J M, Deary I J, Slagboom P E, van Duijn C M, Codd V, Pedersen N L
Abstract excerpt
The association between telomere length (TL) dynamics on cognitive performance over the life-course is not well understood. This study meta-analyses observational and causal associations between TL and six cognitive traits, with stratifications on APOE genotype, in a Mendelian Randomization (MR) framework. Twelve European cohorts (N=17 052; mean age=59.2±8.8 years) provided results for associations between...
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