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Article

TOMM40 genetic variants associated with healthy aging and longevity: a systematic review.

BMC geriatrics - 13 Aug 2022

Chen Sunny, Sarasua Sara M, Davis Nicole J, DeLuca Jane M, Boccuto Luigi, Thielke Stephen M, Yu Chang-En

Abstract excerpt

INTRODUCTION: Healthy aging relies on mitochondrial functioning because this organelle provides energy and diminishes oxidative stress. Single nucleotide polymorphisms (SNPs) in TOMM40, a critical gene that produces the outer membrane protein TOM40 of mitochondria, have been associated with mitochondrial dysfunction and neurodegenerative processes. Yet it is not clear whether or how the mitochondria may impact...

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PMID: 35964003
DOI: 10.1186/s12877-022-03337-4
PMCID: PMC9375314

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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