Article
Suppressed cellular oscillations in after-hours mutant mice are associated with enhanced circadian phase-resetting.
The Journal of physiology - 15 Feb 2013
Guilding Clare, Scott Fiona, Bechtold David A, Brown Timothy M, Wegner Sven, Piggins Hugh D
Abstract excerpt
Within the core molecular clock, protein phosphorylation and degradation play a vital role in determining circadian period. The 'after-hours' (Afh) mutation in mouse slows the degradation of the core clock protein Cryptochrome, lengthening the period of the molecular clock in the suprachiasmatic nuclei (SCN) and behavioural wheel-running rhythms. However, we do not yet know how the Afh mutation affects other...
Topics
- Animals
- Behavior, Animal
- Circadian Clocks
- Circadian Rhythm
- Circadian Rhythm Signaling Peptides and Proteins
- Drinking Behavior
- Energy Metabolism
- Mice
- Mice, Mutant Strains
- Mutation