Article
Disorders of the circadian clock: etiology and possible therapeutic targets.
Current drug targets. CNS and neurological disorders - 1 Dec 2002
Wisor J P
Abstract excerpt
The mammalian circadian clock in the suprachiasmatic nuclei (SCN) of the hypothalamus conveys 24-hr rhythmicity to sleep-wake cycles, temperature, locomotor activity and virtually all other behavioral and physiological processes. In order for these cycles to be adaptive, they must be synchronized, or entrained, to the 24-hr light/dark cycle produced by the rotation of the Earth. The timing of circadian variables...
Topics
- Animals
- CLOCK Proteins
- Chronobiology Disorders
- Drug Delivery Systems
- Humans
- Mutation
- Photic Stimulation
- Suprachiasmatic Nucleus
- Trans-Activators