Cell-cell coupling and DNA methylation abnormal phenotypes in the after-hours mice.

doi:10.1186/s13072-020-00373-5

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Article

Cell-cell coupling and DNA methylation abnormal phenotypes in the after-hours mice.

Epigenetics & chromatin - 6 Jan 2021

Tinarelli Federico, Ivanova Elena, Colombi Ilaria, Barini Erica, Balzani Edoardo, Garcia Celina Garcia, Gasparini Laura, Chiappalone Michela, Kelsey Gavin, Tucci Valter

Abstract excerpt

BACKGROUND: DNA methylation has emerged as an important epigenetic regulator of brain processes, including circadian rhythms. However, how DNA methylation intervenes between environmental signals, such as light entrainment, and the transcriptional and translational molecular mechanisms of the cellular clock is currently unknown. Here, we studied the after-hours mice, which have a point mutation in the Fbxl3 gene...

Topics

Animals
Circadian Rhythm
DNA Methylation
Mice
Mutation
Phenotype
Transcription Factors

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Identifiers

PMID: 33407878
DOI: 10.1186/s13072-020-00373-5
PMCID: PMC7789812

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