Article
The after-hours circadian mutant has reduced phenotypic plasticity in behaviors at multiple timescales and in sleep homeostasis.
Scientific reports - 19 Dec 2017
Maggi Silvia, Balzani Edoardo, Lassi Glenda, Garcia-Garcia Celina, Plano Andrea, Espinoza Stefano, Mus Liudmila, Tinarelli Federico, Nolan Patrick M, Gainetdinov Raul R, Balci Fuat, Nieus Thierry, Tucci Valter
Abstract excerpt
Circadian clock is known to adapt to environmental changes and can significantly influence cognitive and physiological functions. In this work, we report specific behavioral, cognitive, and sleep homeostatic defects in the after hours (Afh) circadian mouse mutant, which is characterized by lengthened circadian period. We found that the circadian timing irregularities in Afh mice resulted in higher interval timing...
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