Article
The mouse Clock mutation reduces circadian pacemaker amplitude and enhances efficacy of resetting stimuli and phase-response curve amplitude.
Proceedings of the National Academy of Sciences of the United States of America - 13 Jun 2006
Vitaterna Martha Hotz, Ko Caroline H, Chang Anne-Marie, Buhr Ethan D, Fruechte Ethan M, Schook Andrew, Antoch Marina P, Turek Fred W, Takahashi Joseph S
Abstract excerpt
The mouse Clock gene encodes a basic helix-loop-helix-PAS transcription factor, CLOCK, that acts in concert with BMAL1 to form the positive elements of the circadian clock mechanism in mammals. The original Clock mutant allele is a dominant negative (antimorphic) mutation that deletes exon 19 and causes an internal deletion of 51 aa in the C-terminal activation domain of the CLOCK protein. Here we report that...
Topics
- Animals
- Biological Clocks
- CLOCK Proteins
- Cell Cycle Proteins
- Circadian Rhythm
- Gene Expression Regulation
- Light
- Mice
- Mice, Inbred Strains
- Motor Activity