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Article

Disturbed clockwork resetting in Sharp-1 and Sharp-2 single and double mutant mice.

PloS one - 23 Jul 2008

Rossner Moritz J, Oster Henrik, Wichert Sven P, Reinecke Lisa, Wehr Michael C, Reinecke Johannes, Eichele Gregor, Taneja Reshma, Nave Klaus-Armin

Abstract excerpt

BACKGROUND: The circadian system provides the basis to anticipate and cope with daily recurrent challenges to maintain the organisms' homeostasis. De-synchronization of circadian feedback oscillators in humans causes 'jet lag', likely contributes to sleep-, psychiatric-, metabolic disorders and even cancer. However, the molecular mechanisms leading to the disintegration of tissue-specific clocks are complex and...

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Identifiers

PMID: 18648504
DOI: 10.1371/journal.pone.0002762
PMCID: PMC2447179

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