Article
The nuclear effector of Wnt-signaling, Tcf1, functions as a T-cell-specific tumor suppressor for development of lymphomas.
PLoS biology - 1 Jan 2012
Tiemessen Machteld M, Baert Miranda R M, Schonewille Tom, Brugman Martijn H, Famili Farbod, Salvatori Daniela C F, Meijerink Jules P P, Ozbek Ugur, Clevers Hans, van Dongen Jacques J M, Staal Frank J T
Abstract excerpt
The HMG-box factor Tcf1 is required during T-cell development in the thymus and mediates the nuclear response to Wnt signals. Tcf1(-/-) mice have previously been characterized and show developmental blocks at the CD4-CD8- double negative (DN) to CD4+CD8+ double positive transition. Due to the blocks in T-cell development, Tcf1(-/-) mice normally have a very small thymus. Unexpectedly, a large proportion of...
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