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Lessons learned from the Eµ-TCL1 mouse model of CLL

10 May 2024

Abstract excerpt

The Eµ-TCL1 mouse model has been used for over 20 years to study the pathobiology of chronic lymphocytic leukemia (CLL) and for preclinical testing of novel therapies. A CLL-like disease develops with increasing age in these mice due to a B cell specific overexpression of human TCL1. The reliability of this model to mirror human CLL is controversially discussed, as none of the known driver mutations identified in...

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PMID: 38839457
DOI: 10.1053/j.seminhematol.2024.05.002

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