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Article

A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development

17 Jun 2016

Abstract excerpt

NFATc1 plays a critical role in double-negative thymocyte survival and differentiation. However, the signals that regulate Nfatc1 expression are incompletely characterized. Here we show a developmental stage-specific differential expression pattern of Nfatc1 driven by the distal (P1) or proximal (P2) promoters in thymocytes. Whereas, preTCR-negative thymocytes exhibit only P2 promoter-derived Nfatc1β expression,...

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PMID: 27312418
DOI: 10.1038/ncomms11841

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