Article
Tcf1 and Lef1 transcription factors establish CD8(+) T cell identity through intrinsic HDAC activity.
Nature immunology - 1 Jun 2016
Xing Shaojun, Li Fengyin, Zeng Zhouhao, Zhao Yunjie, Yu Shuyang, Shan Qiang, Li Yalan, Phillips Farrah C, Maina Peterson K, Qi Hank H, Liu Chengyu, Zhu Jun, Pope R Marshall, Musselman Catherine A, Zeng Chen, Peng Weiqun, Xue Hai-Hui
Abstract excerpt
The CD4(+) and CD8(+) T cell dichotomy is essential for effective cellular immunity. How individual T cell identity is established remains poorly understood. Here we show that the high-mobility group (HMG) transcription factors Tcf1 and Lef1 are essential for repressing CD4(+) lineage-associated genes including Cd4, Foxp3 and Rorc in CD8(+) T cells. Tcf1- and Lef1-deficient CD8(+) T cells exhibit histone...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.