Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response.

Oncogene - 28 Oct 1999

Gazit A, Yaniv A, Bafico A, Pramila T, Igarashi M, Kitajewski J, Aaronson S A

Abstract excerpt

The human homologue of fz1 (Hfz1) was cloned from a cDNA library. Hfz1 was shown to couple to Wnt signal transduction pathways by its ability to enhance Wnt induced TCF dependent transcription in both autocrine and paracrine modes. Enhanced TCF dependent signaling was dose dependent with respect to both Wnt-3A and Hfz1. Moreover, Hfz1 deletion mutants with truncated carboxy termini showed markedly reduced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Frizzled Receptors
Share to Lymphoid Enhancer-Binding Factor 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Receptors, Neurotransmitter

Share to Sequence Analysis

Share to Wnt-5a Protein

Share to Wnt3 Protein

Share to Wnt3A Protein

Share to Wnt4 Protein

Source

Identifiers

PMID: 10557084
DOI: 10.1038/sj.onc.1202985

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response.PMID 10557084Read ↗

The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade.Semantic proximity Read ↗

The nuclear effector of Wnt-signaling, Tcf1, functions as a T-cell-specific tumor suppressor for development of lymphomas.Semantic proximity Read ↗

Wnt target genes and where to find themSemantic proximity Read ↗

Non-canonical WNT/PCP signalling in cancer: Fzd6 takes centre stageSemantic proximity Read ↗

TCF transcription factors: molecular switches in carcinogenesis.Semantic proximity Read ↗

The nuclear receptor Ftz-F1 and homeodomain protein Ftz interact through evolutionarily conserved protein domains.Semantic proximity Read ↗

Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) mice.Semantic proximity Read ↗

Wnt5a can both activate and repress Wnt/β-catenin signaling during mouse embryonic development.Semantic proximity Read ↗

Signaling specificity by Frizzled receptors in Drosophila.Semantic proximity Read ↗

Quantitative Profiling of WNT-3A Binding to All Human Frizzled Paralogues in HEK293 Cells by NanoBiT/BRET AssessmentsSemantic proximity Read ↗

The nuclear hormone receptor Ftz-F1 is a cofactor for the Drosophila homeodomain protein Ftz.Semantic proximity Read ↗

Dfrizzled-3, a new Drosophila Wnt receptor, acting as an attenuator of Wingless signaling in wingless hypomorphic mutants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.