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Article

Epigenetic changes during disease progression in a murine model of human chronic lymphocytic leukemia

28 Jul 2009

Abstract excerpt

Epigenetic alterations, including gain or loss of DNA methylation, are a hallmark of nearly every malignancy. Changes in DNA methylation can impact expression of cancer-related genes including apoptosis regulators and tumor suppressors. Because such epigenetic changes are reversible, they are being aggressively investigated as potential therapeutic targets. Here we use the Emu-TCL1 transgenic mouse model of...

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PMID: 19666576
DOI: 10.1073/pnas.0906455106

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