Article
Beta-catenin and Tcfs in mammary development and cancer.
Journal of mammary gland biology and neoplasia - 1 Apr 2003
Hatsell Sarah, Rowlands Tracey, Hiremath Minoti, Cowin Pamela
Abstract excerpt
Beta-catenin regulates cell-cell adhesion and transduces signals from many pathways to regulate the transcriptional activities of Tcf/Lef DNA binding factors. Gene ablation and transgenic expression studies strongly support the concept that beta-catenin together with Lef/Tcf factors act as a switch to determine cell fate and promote cell survival and proliferation at several stages during mammary gland...
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