Article
beta-Catenin expression enhances generation of mature thymocytes.
International immunology - 1 Dec 2003
Mulroy Thomas, Xu Youyuan, Sen Jyoti Misra
Abstract excerpt
T cell factor (TCF)-1 is a T-cell-specific transcription factor that is expressed at all stages of T cell development. Deletion of the TCF-1 gene leads to an early block in thymocyte maturation precluding the study of its role at late stages and during positive selection of T cells. In this report we show that beta-catenin, a central effector in the Wnt-TCF-1 signaling pathway, regulates late stages of T cell...
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