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Article

PTEN genomic deletion predicts prostate cancer recurrence and is associated with low AR expression and transcriptional activity.

BMC cancer - 22 Nov 2012

Choucair Khalil, Ejdelman Joshua, Brimo Fadi, Aprikian Armen, Chevalier Simone, Lapointe Jacques

Abstract excerpt

BACKGROUND: Prostate cancer (PCa), a leading cause of cancer death in North American men, displays a broad range of clinical outcome from relatively indolent to lethal metastatic disease. Several genomic alterations have been identified in PCa which may serve as predictors of progression. PTEN, (10q23.3), is a negative regulator of the phosphatidylinositol 3-kinase (PIK3)/AKT survival pathway and a tumor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23171135
DOI: 10.1186/1471-2407-12-543
PMCID: PMC3527151

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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PTEN genomic deletion predicts prostate cancer recurrence and is associated with low AR expression and transcriptional activity.PMID 23171135Read ↗

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