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Article

Genomic Rearrangements of PTEN in Prostate Cancer

1 Jan 2013

Abstract excerpt

The phosphatase and tensin homolog gene (PTEN) on chromosome 10q23.3 is a negative regulator of the PIK3/Akt survival pathway and is the most frequently deleted tumor suppressor gene in prostate cancer. Monoallelic loss of PTEN is present in up to 60% of localized prostate cancers and complete loss of PTEN in prostate cancer is linked to metastasis and androgen-independent progression. Studies on the genomic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 24062990
DOI: 10.3389/fonc.2013.00240

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Genomic Rearrangements of PTEN in Prostate CancerPMID 24062990Read ↗

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