Frequent inactivation of PTEN in prostate cancer cell lines and xenografts.

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Article

Frequent inactivation of PTEN in prostate cancer cell lines and xenografts.

Cancer research - 1 Jul 1998

Vlietstra R J, van Alewijk D C, Hermans K G, van Steenbrugge G J, Trapman J

Abstract excerpt

Loss of chromosome 10q is a frequently observed genetic defect in prostate cancer. Recently, the PTEN/MMAC1 tumor suppressor gene was identified and mapped to chromosome 10q23.3. We studied PTEN structure and expression in 4 in vitro cell lines and 11 in vivo xenografts derived from six primary a...

Topics

Animals
Chromosomes, Human, Pair 10
Frameshift Mutation
Gene Deletion
Genetic Markers
Genotype
Humans
Male
Mice
PTEN Phosphohydrolase
Phosphoric Monoester Hydrolases
Prostatic Neoplasms
Protein Tyrosine Phosphatases
RNA, Messenger
Transplantation, Heterologous
Tumor Cells, Cultured
Tumor Suppressor Proteins

Source

Open in PubMed

Identifiers

PMID: 9661880

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9661880-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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