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Article

Frequent inactivation of PTEN in prostate cancer cell lines and xenografts.

Cancer research - 1 Jul 1998

Vlietstra R J, van Alewijk D C, Hermans K G, van Steenbrugge G J, Trapman J

Abstract excerpt

Loss of chromosome 10q is a frequently observed genetic defect in prostate cancer. Recently, the PTEN/MMAC1 tumor suppressor gene was identified and mapped to chromosome 10q23.3. We studied PTEN structure and expression in 4 in vitro cell lines and 11 in vivo xenografts derived from six primary and nine metastatic human prostate cancers. DNA samples were allelotyped for eight polymorphic markers within and...

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Source

Identifiers

PMID: 9661880

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Frequent inactivation of PTEN in prostate cancer cell lines and xenografts.PMID 9661880Read ↗

Loss of a small region around the PTEN locus is a major chromosome 10 alteration in prostate cancer xenografts and cell lines.Semantic proximity Read ↗

PTEN/MMAC1 is infrequently mutated in pT2 and pT3 carcinomas of the prostate.Semantic proximity Read ↗

Genomic Deletion at 10q23 in Prostate Cancer: More Than PTEN Loss?Semantic proximity Read ↗

<i>PTEN</i> genomic deletions that characterize aggressive prostate cancer originate close to segmental duplicationsSemantic proximity Read ↗

Genomic Rearrangements of PTEN in Prostate CancerSemantic proximity Read ↗

PTEN genomic deletion predicts prostate cancer recurrence and is associated with low AR expression and transcriptional activity.Semantic proximity Read ↗

Integrated analysis of the genomic instability of PTEN in clinically insignificant and significant prostate cancer.Semantic proximity Read ↗

Genomic deletion of PTEN is associated with tumor progression and early PSA recurrence in ERG fusion-positive and fusion-negative prostate cancer.Semantic proximity Read ↗

PTEN genomic deletion is associated with p-Akt and AR signalling in poorer outcome, hormone refractory prostate cancer.Semantic proximity Read ↗

Clinical implications of PTEN loss in prostate cancer.Semantic proximity Read ↗

PTEN Protein Loss by Immunostaining: Analytic Validation and Prognostic Indicator for a High Risk Surgical Cohort of Prostate Cancer PatientsSemantic proximity Read ↗

Somatic mutation of PTEN in bladder carcinoma.Semantic proximity Read ↗

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